You've had your first injection. Now you're wondering: when is this supposed to start working?
Short answer: most patients feel appetite changes in the first couple of weeks, and the scale typically starts moving by week 4–6. Here's the full timeline from the team at Medi-Slim Weight Loss & Spa in Las Vegas — what to expect when, and when to talk to your provider if something seems off.
MediSlim has been helping Las Vegas patients with medical weight loss for more than 22 years, long before GLP-1s became a household name. That experience shapes how we set expectations: clearly, honestly, and one patient at a time.
Every patient responds a little differently, so think of this as a general guide — not a fixed schedule.
Your first dose is intentionally low — usually 0.25 mg of semaglutide. Starting low gives your body time to ease in. Most patients feel nothing dramatic in the first few days. Some notice mild stomach sensations a day or two after the injection.
This is where most patients first feel the medication. Hunger gets quieter. Portions that used to feel small suddenly feel satisfying. The "I could eat something" background signal drops. This is often the first real sign it's working — even if the scale hasn't moved.
By this point, many patients are down a few pounds. Clothes start fitting differently. Your provider may also adjust your dose around this time based on how you've responded.
Your dose may continue to be adjusted depending on how you're responding. Weight tends to come off more visibly. Results vary widely between patients — some see steady progress, others move in steps.
By this stage, your appetite has usually settled into a new normal and your provider has found a dose that fits you. The pace of change is highly individual — what matters more than any monthly target is the trend over time.
Weight loss often slows as you approach your body's new equilibrium. This is when maintenance strategy becomes the focus — the habits that will keep the weight off long-term.
Alongside appetite changes, it's normal to feel:
Your provider at MediSlim walks through how to manage each of these so you stay comfortable and on track.
Every few weeks we see a patient who's worried they're not responding. A few things to keep in mind:
Follow-ups are more frequent in the first few months (while your dose is being adjusted) and spread out once you're stable. Your provider checks in on:
Our team — MD, pharmacist, NPs, and MAs — is reachable between appointments, so you're not guessing on your own.
Medi-Slim Weight Loss & Spa is in Las Vegas and serves patients from Henderson, Summerlin, Spring Valley, North Las Vegas, and the surrounding areas. Consultations are paid and by appointment — we don't work with insurance.
Most patients notice appetite changes within the first 1–2 weeks. The scale usually starts moving by week 4–6, though it varies.
Most patients see steady progress over several months, but the timing and amount vary from person to person. Your provider will set realistic expectations based on your starting point.
Yes, completely normal. Appetite tends to quiet first; the scale follows.
No — we're a cash-pay clinic. Pricing is transparent and walked through at your consultation.
We dispense compounded semaglutide. Same active ingredient, prepared by a licensed compounding pharmacy.
Yes — we see patients from across the valley.
Ready to start your timeline? Book a consultation or call (702) 258-8456.
